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KMID : 0984920190210010035
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Journal of Skin Barrier Research
2019 Volume.21 No. 1 p.35 ~ p.40
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Microfluidic Skin-On-A-Chip with Vasculature for Modeling Inflammatory Dermal Diseases
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Kim Seung-Ri
Sung Jong-Hwan
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Abstract
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Animal models have been primarily used for testing skin toxicity and sensitivity. However, animal models have many problems such as ethical issues, costs, time and safety evaluation and prediction are not accurate because there are differences between animals and humans. Therefore, the need for in vitro skin models is increasing. Current in vitro skin model has only a partial function of the skin. In particular, on-chip construction of an in vitro model comprising the epidermis and dermis layer with vascular structure for mass transport has not been reported yet. In this study, we aim to develop a skin on a chip using a three-dimensional skin chip that has fluidic channels and can mimic the human environment more closely. Skin on a chip is a model to reproduce skin reaction similar to human body and physiology by culturing cells constituting skin on chip. In this study, we established cell culture conditions to simulate dermis and epidermis and culture blood vessels, and observed immune response in skin chip. We expect that microfluidic skin on a chip with vasculature can reproduce skin reaction to cosmetic products and drugs and complement animal models.
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KEYWORD
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Microfluidic skin-on-a-chip, Dermal inflammation
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